My research project is part of the broader DFG project “Research in the Context of Practice” led by Martin Carrier. In my research project, I will investigate various research heuristics in order to identify successful strategies, that is, the ones that maximize practical benefits without undermining epistemic robustness. In particular, I consider the following questions: What are the research heuristics that should be employed in order to achieve practical benefits? Does scientific justification and test deteriorate under demand-driven conditions? What role does theoretical understanding play in practically successful models? While the prima facie expectation is that a combination of knowledge-driven and demand-driven research heuristics will work best under certain conditions, my research will test this expectation and try to define the working conditions by considering some current- and maybe also historical- cases of chemical research projects.